Chemyo MK-677 | Review, Benefits, and Dosage

Dr. Mike Jansen

Last Updated September 18, 2022

Dr. Mike Jansen

 September 18, 2022

Curious about Chemyo MK-677?

Trying to figure out if Chemyo MK-677 is the real deal, or just another useless supplement?

Then you’re in the right place. In this comprehensive guide, we detail why Chemyo MK-677 is one of the best legal and natural steroid alternatives on the market.

We will answer your questions, like:

  • What is MK-677?
  • What makes MK-677 so effective?
  • Is Chemyo a reliable MK-677 vendor?

…And much more!

After reading this in-depth guide, you’ll know the history behind MK-677, how to optimally use it, and most importantly, why you might not have much longer to purchase this ‘legal growth hormone alternative’ due to changing laws and regulations.

Always remember to consult a doctor before starting a new supplement regimen, as health and safety should be a priority.

Disclaimer: The contents of are for informational and educational purposes. We do not provide legal advice. Likewise, we do not provide medical advice, diagnosis, or treatment. Please consult your physician prior to consuming any over-the-counter supplements, like a natural testosterone booster, and/or getting a prescription for a pharmaceutical medication. Your access to is subject to our full disclaimer and terms of use.

What is MK-677?

Since it was first synthesized in 1985, synthetic growth hormone has been used for a number of applications – both medically, which it is authorized by the FDA – and for bodybuilding, which the FDA has not approved it for.

Up until recently, if a bodybuilder or strength athlete wanted to add growth hormone to their supplement stack, they would often have to purchase it on the black market, since it’s illegal in most countries to buy growth hormone without a doctor’s prescription [1, 2].

Then, in 1995, MK-677 was developed.

Firstly, as a means of providing an alternative solution to both elderly patients suffering from muscle wasting and bone conditions like osteoporosis.

Following that, MK-677 found its way into the world of bodybuilding as well [3].

MK-677 isn’t exactly growth hormone, although it’s often marketed as a ‘legal growth hormone alternative’ that functions in a similar fashion. It’s actually a growth hormone secretagogue, and it works via four main mechanisms.

It increases GHRH (growth hormone releasing hormone), amplifies GHRH signaling in somatotrophs of the anterior pituitary gland, reduces somatostatin release (somatostatin turns off GH release), and inhibits somatostatin receptor signaling. In other words, MK-677 stimulates the pituitary gland to release more growth hormone naturally.

The problem with most HGH secretagogue peptides is that they cause growth hormone bleeding, which leads to a whole host of adverse side effects.

MK-677 is superior in this sense because it sends intermittent GH pulses throughout the day, rather than causing the body to emit one large, concentrated burst of GH [4].


 What is Chemyo?

Out of all the supplement companies selling MK-677, it can be difficult to determine which ones are legitimate and actually selling products that work.

On top of that, many supplement companies tend to offer poor or even non-existent customer service.

Luckily, none of this is an issue with Chemyo, a US-based pharmaceutical company that is manufacturing and selling SARMs and other supplements.

Over the years, while so many other supplement companies have gone bust, Chemyo has stood strong as one of the leading providers of high-quality SARMs and supplements.

There are a number of factors that set Chemyo apart from all these other supplement companies.

For instance, Chemyo ensures that all their products are lab-tested by an independent third party. They also have batch and lot tracking and triplicate batch analysis, as well as transparent publicly posted HPLC and FTIR raw data, and guaranteed 99% chromatographic purity.

In the spirit of keeping up with an evolving marketplace, Chemyo also accepts cryptocurrency payments.

What’s more, they offer free shipping on US orders over $100 and international orders over $275, as well as free returns on all their products.

“I’ve ordered from Chemyo many times, and the results have always been amazing. Their customer service is outstanding, receiving replies in matter of minutes and resolved my issue very quickly. ‘Kelly’ who sorted the problem with my order was great. Very promptly and professionally sorted the issue. Would 100% recommend.” – Harri H [5].

Benefits of MK-677

Although MK-677 was originally developed to prevent muscle and bone catabolism in elderly patients, as further research has been conducted, numerous benefits for athletes and
bodybuilder have been uncovered.

Before we dive into the benefits of MK-677, it’s important to draw a point of reference based on the benefits you can normally expect to see from taking exogenous human growth hormone (HGH).

Since first being developed in 1985, synthetic growth hormone has mainly been prescribed to treat stunted growth in children, short bowel syndrome, and muscle-wasting diseases.

It’s also been used by bodybuilders to pack on mass, as well as by older individuals who want to regain some of their youthful vigor and enjoy anti-ageing benefits.

Increased Muscle Mass And Strength

MK-677 is unique in that it can help provide many of these benefits without inducing a lot of the adverse side effects normally associated with consuming exogenous GH. One of the primary benefits you can expect to see from MK-677 is improvements in both lean muscle mass and strength [6].

A number of studies have shown that MK-677 can increase IGF-1 levels by between 39-89%, which in turn causes muscles to grow in size.

One research trial in particular found that healthy elderly subjects who consumed MK-677 achieved levels of IGF-1 and growth hormone secretion on par with levels seen in young adults.

Faster Recovery From Exercise

As per its original intentions, numerous studies have shown that MK-677 has been effectively used in several cases to help medical patients recover from injuries. For example, in one randomized, double-blind study that looked at 123 elderly hip fracture patients receiving 25mg/day of MK-677 or placebo, a much more rapid recovery was observed [7].

After 24 weeks had passed, a number of positive signs began to show in the group of participants dosing MK-677.

They were able to walk upstairs at a faster pace compared to the placebo, with their gait speed also increasing. In addition, they experienced less falls during the study compared to the placebo.

On top of that, IGF-1 levels in treated patients increased by 51.4 ng/mL compared to placebo.

In conclusion, it was found that a daily dose of MK-677 stimulates bone turnover in the elderly based on elevations in biochemical markers of bone resorption and formation [6].

Improved Quality Of Sleep

A double-blind, placebo-controlled study involving 8 subjects between the ages of 18-30 also showed that MK-677 can have positive effects on sleep.

Doses were 5 and 25 milligrams of MK-677 and matching placebo.

The high-dose MK-677 treatment resulted in an approximately 50% increase in the duration of stage IV and in a more than 20% increase in REM sleep as compared to placebo. They also found that interruptions to normal sleep decreased from 42% under placebo to 8% under high-dose MK-677.

In essence, the participants in this study experienced deeper, more rejuvenating sleep, as well as deep states of sleep for longer periods without interruptions.

While improved sleep can boost mental cognition and general wellness, it can also greatly accelerate the process of building muscle [8].


Chemyo MK-677 Review

Clocking in at 43 positive reviews, Chemyo MK-677 is one of the best MK-677 products on the market that our team has discovered.

As mentioned above, one advantage that Chemyo MK-677 has over competing products, is that it is third party tested for its identity, purity, and concentration.

This means that they provide full documentation for each product and batch, including IR, GC-MS, LC-MS and HLPC, as opposed to other companies that only provide a certificate of authenticity. Chemyo’s products are all produced in accordance with high standards of quality in an FDA-approved facility in the United States.

We recommend grabbing at least two bottles of Chemyo MK-677 so that you have enough to complete a proper 12-week cycle.

As you can see, there’s a number of reasons why Chemyo MK-677 is our #1 recommended MK-677 supplement. You can learn more and buy pure Chemyo MK-677 here:

Order MK-677 from our top-rated USA vendor...

“I placed my order to the wrong address and they didn’t hesitate to send me another order. Great customer service, arrives fast. Will likely purchase again from here in the future.” – bhasfire

Is MK-677 a Steroid?

Supplements that yield powerful effects tend to be mislabeled as steroids by those who are uninformed.

In reality, there are plenty of bodybuilding supplements available that are not considered steroids at all, and are completely legal to purchase over the counter.

In the case of MK-677, let us clear the air right off the bat by saying that MK-677 is not an anabolic steroid, nor is it a pro-hormone or a SARM. In fact, MK-677 does not even bind to the body’s androgen receptors, which is the primary mode of function of anabolic steroids [9].

As a result, it doesn’t affect the hormonal balance of estrogen and testosterone, whereas anabolic steroid use will temporarily shut down natural testosterone production.

With that said, it’s also unnecessary to take post-cycle therapy supplements, otherwise abbreviated as PCT.


Is MK-677 Legal?

Another misconception that we’ve touched on briefly in this article is that MK-677 is whether or not MK-677 is a SARM.

In addition, due to the nature of MK-677’s effects leading to increased growth hormone and IGF-1 production, some might be under the impression that MK-677 is regarded in the same way as regular growth hormone, and that a prescription is necessary to legally purchase MK-677.

Let’s be clear once again: MK-677 is not a SARM, nor is it classified the same way as regular growth hormone.

A key point to take into account here, is that the legalities surrounding SARMs and human growth hormone in many countries therefore do not apply to MK-677.

Since MK-677 is not classified as an anabolic steroid or SARM, it is completely legal to purchase, possess, or consume in several countries, such as the United States, Canada, the UK, and Australia.

While there are no restrictions on buying and using MK-677 in a number of countries, such as the United Kingdom and the United States, the rules are a bit different when it comes to professional sports.

The governing body responsible for determining which substances can be allowed to be consumed in professional competitive sports, the World Anti-Doping Agency (WADA), has banned MK-677 and placed it under category S2 of prohibited substances.

This means that athletes competing at the highest levels of sport, such as the Olympics or the IFBB, are not allowed to have MK-677 in their system when competing [10].

MK-677 and Bodybuilding

Since its inception in 1985, synthetic growth hormone has been one of the most powerful performance enhancing substances used by bodybuilders to date.

Unfortunately, in many jurisdictions, growth hormone can only be legally purchased and consumed with a doctor’s prescription. As a way to bypass this legal roadblock, some athletes may opt to buy GH from a black market source.

Not only is it illegal in many countries to purchase GH without a prescription, but the product purchased may not even be legitimate [9].

This is one of the main reasons why MK-677 has been so well-received by the bodybuilding community, since it solves many of the problems associated with GH.

While MK-677 certainly doesn’t produce the effects of HGH with the same level of potency, multiple studies have shown that it does indeed provide a number of benefits – namely, increased levels of GH and IGF-1 [10].

This growth hormone secretagogue is currently available in capsules and liquid form, which makes it easy to take with food or mixed into a beverage.

This effectively eliminates the need for injections, which are commonplace when using steroids or growth hormone.

When it comes to using MK-677 for bodybuilding purposes, it’s essential to keep in mind that this growth hormone secretagogue has a bell curve dose response ratio. In other words, this means that taking 12.5mg per day will generally increase HGH and IGF-1 levels by 150% while taking a higher dose of 25mg will increase HGH Levels 190%-200%.

After that, an increased dosage will yield diminished returns [11].

Chemyo MK-677 | Verdict

In conclusion…

MK-677 is one of the most promising growth hormone alternatives on the market today.

Based on several studies mentioned in this article, MK-677 is a generally safe compound, and is already being widely accepted as a supplement of choice by those who want to see improvement in their performance.

The biological mechanism of MK-677 and availability in capsule and liquid form make consuming MK-677 a much less inconvenient experience than having to inject exogenous growth hormone.

This is good news for athletes and bodybuilders who are not prepared or willing to experiment with substances like GH that have a higher potential for causing adverse effects.

If you are looking for a great MK-677 product, then we strongly recommend Chemyo MK-677.

Why? Chemyo has one of the most reviewed MK-677 products. They also let customers view authentic lab documents, proving their product contains the highest quality ingredients.

Here is where you can learn more:

Order MK-677 from the best USA vendor...


  1. Human growth hormone (HGH) laws. HGH. (n.d.). Retrieved May 8, 2022, from
  2. Dunkin, M. A. (n.d.). HGH (human growth hormone): Uses and side effects. WebMD. Retrieved May 8, 2022, from
  3. Ishida, J., Saitoh, M., Ebner, N., Springer, J., Anker, S. D., and von Haehling, S. (2020) Growth hormone secretagogues: history, mechanism of action, and clinical development. JCSM Rapid Communications, 3: 25– 37.
  4. M. G. Murphy, L. M. Plunkett, B. J. Gertz, W. He, J. Wittreich, W. M. Polvino, D. R. Clemmons, MK-677, an Orally Active Growth Hormone Secretagogue, Reverses Diet-Induced Catabolism, The Journal of Clinical Endocrinology & Metabolism, Volume 83, Issue 2, 1 February 1998, Pages 320–325,
  5. Chemyo is rated “excellent” with 4.6 / 5 on Trustpilot. Trustpilot. (2022, April 29). Retrieved May 8, 2022, from
  6. Dr. Idiberto Jose Zotarelli Filho, M. S. (2020, May 23). Major approaches the use of GH secretagogue (MK-677) for muscle mass gain in elderly: A brief systematic review. Authorea. Retrieved May 3, 2022, from
  7. Smith, R. G. (2005, May 1). Development of growth hormone secretagogues. OUP Academic. Retrieved May 3, 2022, from
  8. Copinschi, G., Leproult, R., Onderbergen, A. V., Caufriez, A., Cole, K. Y., Schilling, L. M., Mendel, C. M., Lepeleire, I. D., Bolognese, J. A., & Cauter, E. V. (2008, April 9). Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man. Neuroendocrinology. Retrieved May 5, 2022, from
  9. Steroid side effects: How to reduce corticosteroid side effects. Hospital for Special Surgery. (n.d.). Retrieved May 8, 2022, from
  10. The prohibited list. World Anti-Doping Agency. (2022, February 9). Retrieved May 5, 2022, from
  11. Nass R, Pezzoli SS, Oliveri MC, et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med. 2008;149(9):601-611. doi:10.7326/0003-4819-149-9-200811040-00003
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