Is MK-677 Safe? | What You MUST Know

Daniel Louwrens

Last Updated September 5, 2022

Daniel Louwrens

 September 5, 2022

Curious… is MK-677 safe?

Then you’ve come to the right place, as we detail exactly what this over-the-counter supplement is and why athletes love it – while also detailing side effects and any safety concerns.

We’re all concerned with safety, and rightfully so. In recent years it’s become evident that the world of performance enhancing supplements has boomed, but some have tried taking advantage of your fellow Joe.

So, are you curious; is MK-677 Safe? In this guide, we will tell you everything you MUST know about the safety of MK-677.

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What is MK-677?

MK-677 is a growth hormone secretagogue that was originally developed and patented in the 1990’s. This means that MK-677 would stimulate the user’s own pituitary gland to produce more endogenous Growth Hormone. MK-677 was originally intended to be used by individuals suffering from muscle wasting diseases, or who simply had a growth hormone deficiency [1, 2].

A patient with a growth hormone deficiency may have have symptoms such as increased adipose tissue, general feeling of unwell being, increased cholesterol levels, muscle wastage, and inability to handle the heat and cold. While not extremely common, it is estimated that up to 0.03% of the world’s population suffer from growth hormone deficiency [3, 4].

Medical professionals would usually administer exogenous growth hormone to correct this deficiency in patients. However, MK 677 has been developed as a new research chemical.

MK-677 is sometimes lumped together with SARMs, or Selective Androgen Receptor Modulators. However, the reality is that MK-677 is not a SARM at all. Compared to SARMs and Steroids, which would bind to Androgen receptors in muscle and bone tissue, MK-677 has only been shown to stimulate the pituitary gland to produce more growth hormone in human subjects.

MK-677 has been shown to have the following effects on research subjects [5, 6, 7, 8]:

  • Increased level of Growth Hormone. Higher levels of Growth Hormone has been linked to fat loss, better skin health, better hair health, better recovery from exercise, and better muscular hypertrophy
  • Increased levels of IGF-1 (Insulin-like Growth Factor 1). Higher IGF-1 levels will have a dramatic impact on muscular adaptation and hypertrophy
  • Improved bone health. Some studies have shown that MK-677 can increase bone strength and bone health in elderly research subjects
  • Improved Sleep. Some studies have found that MK-677 can help research subjects who are suffering from sleep ailments by improving sleep quality as well as correcting relative hypogonadotropic of senescence.
  • Combats Aging. Growth hormone is known to help subjects look and feel younger.

MK-677


Is MK-677 Safe?

Now that it has been established that MK 677 can indeed have physiological benefits, the next logical thing to look at its safety in humans. It has to be mentioned again, that even though MK 677 is often grouped with SARMs, it is not in any way, shape, or form a real SARM. It is technically a research chemical, and it does not bind to androgen receptors the same way that SARMs and steroids do.

MK-677 will simply stimulate the pituitary gland to produce more growth hormone. This in turn will induce the generation of IGF-1 levels within the liver which can help with muscular growth. Growth Hormone will also downregulate the uptake of free fatty acids into adipocytes, while simultaneously encouraging the body to use those free fatty Acids as fuel.

While MK-677 has been tested in the medical field, and has been extensively tested by independent researches, more scientific research is required That being said, studies have found MK 677 to be quite safe in human subjects. For instance:

  •  A study published in 1997 found that neither the usage of 10mg or 50mg of MK-677 led to adverse effects [1].
  • A 2-year study published in 2008 found that MK-677 administration found only minor side effects such as increased apatite, but subsided over a few months [2].
  • A study published in 2020 found that not only could MK-677 be a sarcopenia treatment option, but had no adverse effects on the test subjects [6].

While still classified as a research chemical, these and other studies show that MK 677 seems to be safe for usage, when taken at reasonable doses.


MK-677 Side Effects and Safety Concerns

Of course, everything does have side effects. In fact, the reason why MK-677 is still recognized as a research chemical is because further testing is still needed to identify the effects in full.

That being said, MK 677 can have the following side effects [8, 9, 10, 11, 12]:

  •  Increased Hunger. MK-677 is a ghrelin mimic. Ghrelin is the “hunger” hormone and will signal the brain that food is needed. MK-677 has been shown to increase hunger, but effects can taper down.
  • Insulin Resistance. As growth hormone levels increase in the body, the body will undergo higher levels of gluconeogenesis and lipolysis. This in turn can cause hyperglycemia and elevated free fatty acid levels. When MK-677 is combined with a calorie restrictive diet, this isn’t a great concern. However if combined with a diet of excess calories, this can lead to insulin resistance.
  • Increased Water Retention. A common side effect of using exogenous growth hormone is suffering from increased water retention. Growth hormone is known to be an activator of the renal transporter of sodium. Increased water retention can sometimes lead to an increase in blood pressure.

Even though MK 677 is a research chemical, there seems to very few if any safety concerns regarding the compound. The only thing that is important to note is that adverse effects will be kept at bay if you follow a reasonable dose.


MK-677


MK-677 Dosage and Cycle

When it comes to the actual dosing of MK-677, it is important to note that a cycle longer than 12 weeks or 3 months is not advised. While there is technically no minimum time you need to run MK-677 to get the positive effects, a cycle ranging from 8 – 12 Weeks is a good place to start.

There are various studies testing different dosages of MK 677, ranging from 10mg to 50mg per day. The most advantageous dosing was found to be at around 10 – 25 mg per day. Doses higher than 50mg per day have not been researched and should be avoided at all costs.

Studies on human subjects have shown that using MK-677 at a dose of 10mg per day for 8 – 12 weeks is enough to see significant benefits. That being said, research studies show that doses as high as 25mg per day have additional benefits in human subjects with no apparent adverse side effects [1].


MK-677 and Bodybuilding

Bodybuilders have the singular goal of being as big and lean as possible on the day of their bodybuilding competition. Bodybuilders will not only use a vast array of anabolic steroids, but will also use exogenous Growth Hormone to reap the fat loss and muscular hypertrophy benefits. This creates a problem as exogenous growth hormone is known to downregulate the production of endogenous growth hormone [13].

Research studies show that a growth hormone secretagogue like MK-677 may help subjects to boost Growth Hormone and IGF-1 levels without shutting down their own endogenous growth hormone production.


Is MK-677 Legal?

MK 677 falls under the umbrella of SARMs, which are legal to purchase, under certain circumstances. MK 677 may only be sold labeled as a research chemical, and with the phrase “not for human consumption” somewhere on the product.

Other SARMs have to be sold under the same conditions, as more research is needed on these products before they will be approved by the FDA


Best MK-677 Supplements | 2022 Edition

MK-677 clearly has benefits for research subjects when administared in the right situation. The best MK-677 supplement we can recommend will have to be the MK-677 produced and sold by Chemyo. Chemyo is an American based company aiming to produce exceptionally good quality research chemicals at a cost-effective price.

Not only is their MK 677 cost-effective, it has also undergone third party testing, and is also available in a 50ml container, which is sure to keep you stocked up for a long time. Both the MK 677 and the company have great reviews on their site and on independent sites, like Reddit.

Order MK-677 from the best USA vendor...


Is Beta-MK-677 Safe? | Verdict

Most Research Chemicals need quite a bit more research done on their safety. The only one that has been proven to be safe and effective in human subjects is MK-677. It is a growth hormone secretagogue that shows very little adverse effects, and even the ones that are present are easily managed.

MK-677 could have beneficial effects on a fat loss phase, as well as just increasing the quality of life. This research chemical has a lot going for it, including remarkable safety.


References

  1. Ian M. Chapman, Ora H. Pescovitz, Gail Murphy, Theresa Treep, Kristine A. Cerchio, David Krupa, Barry Gertz, William J. Polvino, Emily H. Skiles, Suzan S. Pezzoli, Michael O. Thorner, Oral Administration of Growth Hormone (GH) Releasing Peptide-Mimetic MK-677 Stimulates the GH/Insulin-Like Growth Factor-I Axis in Selected GH-Deficient Adults, The Journal of Clinical Endocrinology & Metabolism, Volume 82, Issue 10, 1 October 1997, Pages 3455–3463, https://doi.org/10.1210/jcem.82.10.4297
  2. Nass R, Pezzoli SS, Oliveri MC, et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med. 2008;149(9):601-611. doi:10.7326/0003-4819-149-9-200811040-00003
  3. Ayuk J, Sheppard MC. Growth hormone and its disorders. Postgrad Med J. 2006;82(963):24-30. doi:10.1136/pgmj.2005.036087
  4. Feldt-Rasmussen U, Klose M. Adult Growth Hormone Deficiency Clinical Management. [Updated 2017 Mar 24]. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK425701/
  5. M. G. Murphy, L. M. Plunkett, B. J. Gertz, W. He, J. Wittreich, W. M. Polvino, D. R. Clemmons, MK-677, an Orally Active Growth Hormone Secretagogue, Reverses Diet-Induced Catabolism, The Journal of Clinical Endocrinology & Metabolism, Volume 83, Issue 2, 1 February 1998, Pages 320–325, https://doi.org/10.1210/jcem.83.2.4551
  6. Dr. Idiberto Jose Zotarelli Filho, MSc, Ph.D. MAJOR APPROACHES THE USE OF GH SECRETAGOGUE (MK-677) FOR MUSCLE MASS GAIN IN ELDERLY: A BRIEF SYSTEMATIC REVIEW. Authorea. May 26, 2020.
  7. Devesa J, Almengló C, Devesa P. Multiple Effects of Growth Hormone in the Body: Is it Really the Hormone for Growth?. Clin Med Insights Endocrinol Diabetes. 2016;9:47-71. Published 2016 Oct 12. doi:10.4137/CMED.S38201
  8. Copinschi G, Leproult R, Van Onderbergen A, Caufriez A, Cole KY, Schilling LM, Mendel CM, De Lepeleire I, Bolognese JA, Van Cauter E. Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man. Neuroendocrinology. 1997 Oct;66(4):278-86. doi: 10.1159/000127249. PMID: 9349662.
  9. Hoffman DM, Crampton L, Sernia C, Nguyen TV, Ho KK. Short-term growth hormone (GH) treatment of GH-deficient adults increases body sodium and extracellular water, but not blood pressure. J Clin Endocrinol Metab. 1996 Mar;81(3):1123-8. doi: 10.1210/jcem.81.3.8772586. PMID: 8772586.
  10. Lampit M, Nave T, Hochberg Z. Water and sodium retention during short-term administration of growth hormone to short normal children. Horm Res. 1998;50(2):83-8. doi: 10.1159/000023239. PMID: 9701701.
  11. Pradhan G, Samson SL, Sun Y. Ghrelin: much more than a hunger hormone. Curr Opin Clin Nutr Metab Care. 2013;16(6):619-624. doi:10.1097/MCO.0b013e328365b9be
  12. Wilcox G. Insulin and insulin resistance. Clin Biochem Rev. 2005;26(2):19-39.
  13. Rosenthal SM, Hulse JA, Kaplan SL, Grumbach MM. Exogenous growth hormone inhibits growth hormone-releasing factor-induced growth hormone secretion in normal men. J Clin Invest. 1986;77(1):176-180. doi:10.1172/JCI112273
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