Laxogenin Side Effects | What You MUST Know

Dr. Mike Jansen

Last Updated December 17, 2022

Dr. Mike Jansen

 December 17, 2022

Curious about laxogenin side effects?

Do you wonder if laxogenin is safe, or if it has long-term safety concerns?

Then you’ve come to the right place. In this comprehensive guide, we detail everything you need to know about laxogenin side effects, including the best laxogenin dose to take on a daily basis.

We’ll also be answering your most important questions, including:

  • Do I have to cycle laxogenin?
  • Does laxogenin impact hormone levels?
  • Are there any risks associated with laxogenin?

…And so much more!

Here at, our team has analyzed all the latest scientific literature to give you fact-based answers to all of your most important questions.

Of course, at the end of the day you get to decide whether you want to add laxogenin to your supplement stack to speed up your progress in the gym.

Now let’s get started!

Disclaimer: The contents of are for informational and educational purposes. We do not provide legal advice. Likewise, we do not provide medical advice, diagnosis, or treatment. Please consult your physician prior to consuming any over-the-counter supplements, like a natural testosterone booster, and/or getting a prescription for a pharmaceutical medication. Your access to is subject to our full disclaimer and terms of use.

What is Laxogenin?

Laxogenin is one of the most popular “legal steroid alternatives” on the market today. But what is it, and why do some people think it works for boosting muscle mass?

Laxogenin belongs to a family of natural plant steroids called “brassinosteroids.” These compounds increase protein synthesis in plants, and play a key role in their overall growth and development (1, 2).

Many plant steroids, such as ecdysterone, have been shown to boost protein synthesis in animal and human studies (3, 4). Therefore, some people believe that brassinosteroids such as laxogenin may have similar muscle-building effects.

Laxogenin is commonly derived from the plant smilax sieboldii.

However, other plants such as the Chinese onion allium chinense also contain significant amounts of laxogenin (5, 6).

Structurally, laxogenin is very similar to the molecule testosterone. However, unlike testosterone, laxogenin does not bind to the androgen receptors in humans. Instead, it is theorized to work by directly increasing muscle protein synthesis inside the muscle cells, without impacting your hormone levels.

This is good news for anyone who is interested in building muscle mass and strength as a “natural athlete.”

The research on laxogenin is still in its infancy.

Only a small number of animal studies have been performed studying the potential muscle-building effects of laxogenin supplementation (7, 8).

To date, no human studies have been performed on the compound, although that may change in the future, based on the positive results many people are seeing with this natural plant steroid.

Laxogenin Side Effects

Laxogenin Benefits

Laxogenin is a relatively new supplement. However, many users are already reporting serious benefits from this “natural plant steroid.”

Here are some of the most commonly reported benefits of laxogenin:

  • Bigger, leaner physique
  • Rapid recovery between workouts
  • Faster strength gains
  • Improved exercise performance
  • Decreased stress levels

Let’s take a closer look at each of these benefits.

The primary benefit that first-time users report while taking laxogenin is a bigger, leaner physique.

Many experts say that it’s impossible to build muscle mass and lose body fat at the same time. There is some truth to this statement.

However, many users report they look bigger AND leaner after the first 2-3 weeks of their laxogenin cycle.

If this is true, then it may be related to laxogenin’s ability to boost muscle protein synthesis.

We know that laxogenin and other brassinosteroids boost protein synthesis in plants, so it’s possible the same thing is happening in humans. We’ll have to wait for more research studies to pinpoint exactly what’s going on, but the anecdotal evidence is very promising so far.

Other reported benefits of laxogenin include rapid recovery between workouts, faster strength gains, improved exercise performance, and decreased stress levels.

As you can see, users are reporting a wide range of benefits from laxogenin.

We recommend you track your progress during your first laxogenin cycle, so you can figure out for yourself if laxogenin gives you similar benefits.

Laxogenin Side Effects

Laxogenin is a relatively safe supplement.

Most users report few, if any, side effects while taking laxogenin. However, there are a few side effects that you should be aware of before trying this product.

Here are some of the most common side effects reported while cycling laxogenin:

  • Minor headaches
  • Nausea / upset stomach
  • Diarrhea
  • Kidney damage
  • Heavy urination

Let’s take a closer look at each of these side effects.

Based on our research, minor headaches is the most common side effect reported by new users of laxogenin.

Some users report that they have very minor headaches 1-2 hours after taking the supplement, or while working out.

If you experience any type of headache while taking laxogenin, then a simple solution would be to take a smaller dose, or to take laxogenin with a whole food meal to improve absorption of the product.

Of course, without any human studies on laxogenin it’s hard to say why some users experience minor headaches, while others do not.

Another one of the most commonly reported side effects while taking laxogenin is nausea and / or an upset stomach. This is a common symptom with many different supplements, including pre-workout supplements and even other “legal steroid alternatives” like ecdysterone or turkesterone.

The minor stomach discomfort experienced while taking laxogenin may be caused by improper breakdown and absorption of the product.

An easy solution to this problem would be to reduce the dosage, to spread out your laxogenin dosage throughout the day, or to take the supplement with a whole food meal.

Most users who experience stomach discomfort while taking laxogenin reported they were taking at least 200 mg per dose, so using a smaller dose of 100 mg at a time may alleviate this problem.

Other potential side effects while taking laxogenin include diarrhea, kidney damage, or frequent urination.

Our team at was NOT able to find any verified user reviews which listed these symptoms. However, other resources on laxogenin included diarrhea, kidney damage, and frequent urination as potential side effects, so we decided to include them to be as thorough as possible.

Your kidneys are responsible for filtering your blood, so if you were to take too much of any supplement, then that may put unnecessary stress on them.

If you are experiencing frequent urination or anything similar, then a logical decision would be to lower your laxogenin dose, or to discontinue using the product.

Of course, we will have to wait for further animal and human studies to gather more information on the most common side effects related to laxogenin.

However, based on reviews from verified customers, these are the most common ones that you may experience while taking this legal steroid alternative.

Laxogenin Side Effects

Is Laxogenin Safe?

Is laxogenin really as safe as everyone says it is? Let’s look at the facts before jumping to any conclusions.

Based on our research, here are the reasons why laxogenin is probably safe for human consumption:

  • Does not impact hormones
  • Does not require a PCT
  • Few user-reported side effects
  • Natural plant steroid

Let’s take a closer look at each of these factors.

Unlike traditional anabolic steroids, laxogenin does NOT impact your hormone levels. This means it doesn’t have any serious side effects, and you don’t have to use a post-cycle therapy after finishing your first laxogenin cycle.

Most people who complete their first cycle of laxogenin report few, if any, side effects.

In rare cases, someone will report mild stomach discomfort while using laxogenin. This can be remedied by using a smaller dose, or taking laxogenin with a whole food meal.

Finally, other natural plant steroids like ecdysterone and turkesterone are also perfectly safe, so it makes sense that laxogenin would be as well. Based on our research, laxogenin appears to be perfectly safe with few, if any, side effects.

Of course, further research is required to confirm this statement.

Is Laxogenin a Steroid?

Laxogenin is one of the most powerful legal steroid alternatives on the market today. But is laxogenin similar to traditional anabolic steroids?

The answer is no – laxogenin is NOT an anabolic steroid.

It does not impact your hormone levels, such as your free or total testosterone, so you don’t have to worry about the long-term side effects that come with traditional anabolic steroids.

Most laxogenin users choose to cycle the product for 6-12 weeks at a time. This is probably a good idea, as there are no long-term studies on the safety of laxogenin.

However, overall laxogenin appears to be a safe and effective alternative to traditional anabolic steroids.

Laxogenin Side Effects

Does Laxogenin Suppress Testosterone?

You may be wondering if laxogenin suppresses men’s testosterone levels. After all, most users choose to “cycle” laxogenin for 6-12 weeks at a time before taking a break from the product.

Fortunately, the answer is very simple: no, laxogenin does NOT suppress men’s testosterone levels.

Instead, it works by boosting protein synthesis levels in your muscle cells, with no impact on your hormones.

This is great news, as it means you don’t have to use a post-cycle therapy after using the product.

More research is required to confirm these statements. However, thousands of verified customers have used laxogenin, and based on our research, no one has reported a decline in their total testosterone levels while using the product.

Does Laxogenin Work?

Laxogenin is one of the most popular “legal steroid alternatives” in the world. But does it actually work?

Based on anecdotal evidence, laxogenin appears to work extremely well for building muscle mass and strength.

Most laxogenin users report rapid increases in size and strength, as well as other benefits like faster recovery ability and improved quality of sleep.

So far, no long-term research studies have been performed on laxogenin. However, the feedback from thousands of verified customers shows that laxogenin works extremely well for most individuals.

Laxogenin Side Effects

Best Laxogenin Supplements

Without further ado, here is the list of the best laxogenin supplements available in 2023.

1. Sapogenix

Without a doubt, Huge Supplements Sapogenix is our #1 recommendation for a reliable and effective laxogenin supplement in 2023.

This isn’t just our opinion though – hundreds of customers have already used Sapogenix with incredible results.

Sapogenix is different from other laxogenin products because it contains several different natural plant steroids, including laxogenin, 6-keto-disogenin, spirostanol sapogenins, furastanolic sapogenins, and many other natural plant steroids.

These ingredients work synergistically to boost protein synthesis and give you superior results.

Huge Supplements also has a very strict manufacturing process, so you know you are getting a superior quality product. They produce all of their supplements right here in the United States under FDA-regulated facilities.

Finally, the shipping and customer service at Huge Supplements is also top-notch.

Servings: 60

Amount per serving: 250 mg

Order Laxogenin from our top-rated USA vendor...

2. Annihilate

Huge Supplements sells another high-quality laxogenin product called Annihilate.

The thing that makes Annihilate different is it contains 100% pure laxogenin and no other ingredients. Of course, it still uses Huge

Supplements’ cyclosome delivery technology to maximize absorption.

If you are looking for a high-quality laxogenin product that won’t break the bank, then Annihilate is an excellent choice.

Servings: 60

Amount per serving: 100

Order the best Laxogenin from Huge Supplements...

3. Halo

Redcon1 is one of the most trusted names in the fitness industry.

They produce military grade supplements right here in the United States using premium quality ingredients.

If you are looking for a high-quality laxogenin supplement to give you an extra boost in the gym, then Redcon1 Halo is a great choice.

Servings: 60

Amount per serving: 100

Here is where you can learn more.

Side Effects of Laxogenin | Overall

In conclusion…

Laxogenin is an extremely popular “legal steroid alternative” in 2023.

People all over the world are using laxogenin to transform their physique in record time. In fact, laxogenin is so effective that many people wonder if it has any long-term side effects, such as those associated with anabolic steroids.

Laxogenin is a relatively new product, and very few research studies have been performed on this product.

Therefore, it’s hard to know for sure if this product has any serious side effects that you should be aware of. However, based on our research, most users do not experience any side effects while taking laxogenin.

In rare cases, some users will report minor side effects, such as nausea or headaches.

Here at, we believe the best strategy to minimize side effects is to take no more than 100 – 200 mg of laxogenin per day. We also recommend “cycling” laxogenin for 6-12 weeks at a time, followed by a 4-8 week break from the product.

So what are you waiting for?

Pick up a bottle of Huge Supplements laxogenin today and watch your gains shoot through the roof!


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  2. Wang Q, Xu J, Liu X, Gong W, Zhang C. Synthesis of brassinosteroids analogues from laxogenin and their plant growth promotion. Nat Prod Res. 2015;29(2):149-57. doi: 10.1080/14786419.2014.968151. Epub 2014 Oct 14. PMID: 25311045.
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  6. Baba M, Ohmura M, Kishi N, Okada Y, Shibata S, Peng J, Yao SS, Nishino H, Okuyama T. Saponins isolated from Allium chinense G. Don and antitumor-promoting activities of isoliquiritigenin and laxogenin from the same drug. Biol Pharm Bull. 2000 May;23(5):660-2. doi: 10.1248/bpb.23.660. PMID: 10823685.
  7. Esposito D, Komarnytsky S, Shapses S, Raskin I. Anabolic effect of plant brassinosteroid. FASEB J. 2011;25(10):3708-3719. doi:10.1096/fj.11-181271
  8. Esposito D, Rathinasabapathy T, Poulev A, Komarnytsky S, Raskin I. Akt-dependent anabolic activity of natural and synthetic brassinosteroids in rat skeletal muscle cells. J Med Chem. 2011;54(12):4057-4066. doi:10.1021/jm200028h
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