MK-677 Benefits | What You MUST Know about this HGH Booster

Daniel Louwrens

Last Updated December 29, 2022

Daniel Louwrens

 December 29, 2022

Curious about MK-677 benefits? Then you’re in the right place, as we detail why so many athletes and bodybuilders have been using this over-the-counter supplement as of late.

MK 677 has been all the rave lately, with claims of not only being good for building muscle and losing fat, but also being exceptional from a longevity standpoint. It’s time we took a deep dive into what is found in reality about this research chemical.

Disclaimer: The contents of are for informational and educational purposes. We do not provide legal advice. Likewise, we do not provide medical advice, diagnosis, or treatment. Please consult your physician prior to consuming any over-the-counter supplements, like a natural testosterone booster, and/or getting a prescription for a pharmaceutical medication. Your access to is subject to our full disclaimer and terms of use.

What is MK-677?

In case you haven’t noticed, SARMs, or Selective Androgen Receptor Modulators, have been taking the health and fitness industry by storm. These research chemicals were developed to replace steroids in the medical field, as they have less androgenic side effects than many traditional anabolic steroids.

MK-677 often gets classified as a SARM. However, in reality MK-677 is not a SARM, or even a research chemical. MK-677 is technically a research chemical. MK 677 was originally patented in 1995 as a growth hormone secretagogue.

This chemical does not bind to the androgen receptors in the body in the way that SARMs and anabolic steroids do. Instead, it binds to the pituitary gland located inside the research subject’s brain. MK-677 was developed as a medical research chemical to enhance the release of growth hormone in individuals who are suffering from a growth hormone deficiency [1, 2].

Research shows that individuals with low growth hormone may suffer from a variety of symptoms, including increased adipose tissue, depression, fatigue, sensitivity to heat and cold, and a general feeling of illness [3].

Studies have shown that MK-677 can increase growth hormone and IGF-1 production in otherwise healthy research subjects. Researchers have shown that MK-677 has many physiological benefits for healthy males such as increased muscle retention, increased fat loss, and increased recovery rates between training sessions [1, 2].


MK-677 Benefits

As beforementioned, the main benefit of using MK-677 is going to be the ability to stimulate the release of Growth Hormone and IGF-1 into the body. Compared to just using exogenous growth hormone, MK-677 will not downregulate the subjects own endogenous production of growth hormone.

Benefits of MK-677 include [2, 4, 5, 6, 7]:

  • Increased levels of Growth Hormone levels. Increased growth hormone levels have been associated with increased fat loss, improved muscle recovery, muscle hypertrophy, as well as a general increase in life quality. Increased growth hormone levels can also increase recovery rates between injuries as it can promote the growth of cartilage.
  • Increased levels of IGF-1. IGF-1 can significantly increase muscle growth capabilities. This is because IGF-1 can potentiate skeletal muscle by activating stem (satellite) cells, which in the long run will dramatically improve muscular hypertrophy.
  • Increased Bone Density. Some studies have shown that MK-677 has been linked to improved bone health and density, which in turn can not only help with strength training, but can improve everyday functionality as well.
  • Improved Sleep. A study published in 1998 found that MK-677 can significantly improve sleep quality as well as help with correcting relative hypogonadotropic of senescence.
  • Combats Aging. Growth hormone has the nickname of “the youth drug”, as it’s effects on joint -, skin -, and mental health are quite advantageous. By stimulating the release of endogenous growth hormone, it has many of the same effects.

The great thing about MK-677 is that it will not down regulate the production of endogenous Growth Hormone. Using exogenous Growth Hormone has been found to downregulate production [8]. Therefore, using a growth hormone secretagogue (something that just increases endogenous production of Growth Hormone) could be more advantageous in the long run

Is MK-677 Safe?

MK 677, like most research chemicals, must still undergo a great deal of research before any blanket statements can be made. That being said, there are plenty of studies showing that MK-677 is perfectly to use with research subjects.

While MK-677 is safe to administer in controlled studies, it does come with some side effects: [9, 10, 11, 12, 13]:

  • Increased Insulin Resistance. With an increase in growth hormone levels in the body, we see a corresponding increase in levels of free fatty acids due to lipolysis. While this is perfect from a fat loss perspective, if the individual isn’t following a calorie restricting diet, it may lead to insulin resistance. Insulin resistance can lead to an increase in adipose tissue, and if left untreated, could lead to more serious complications like a pre diabetic state.
  • Increased Water Retention. Growth Hormone is known to increase water retention in the body, since it is an activator of the renal transporter of sodium. Increased water retention has been linked to a corresponding increase in blood pressure.
  • Increased Apatite. MK-677 is a mimic of the ghrelin hormone, which can signal the brain that the individual needs food, thus increasing hunger.

While MK-677 has been shown to be safe in a few studies, various independent researches have been using MK 677 for the physiological benefits, and few if any, experience significant adverse effects. That being said, more academic research is needed.

How to Take MK-677 | What You MUST Know

Like with most research chemicals on the market today, MK 677 comes in various forms to administer to the body. These include:

  • Powdered MK-677
  • Injectable MK-677
  • Oral Liquid Mk-677
  • Oral Capsule MK-677

Each of the administration methods will have its own benefits and drawbacks, such as the fact that using an oral liquid version of MK-677 does not require piercing of the skin, which lowers the risk of infection.

Because of the side effects associated with MK-677, which have been discussed above, research subjects who use MK-677 will be limited with the number of cycles they can run over the period of a year. The biggest concern would simply be checking blood pressure, resting blood glucose levels, as well as cholesterol levels. If these are in check, subjects could be looking at using MK-677 for 1 – 2 cycles per year to reap the rewards of increased growth hormone.

If taken in an environment where calories are not restricted, it would also be beneficial to keep watch on your resting blood sugar and glucose levels, as it has been shown that MK 677 can increase insulin sensitivity. This would usually be undone if the user would to use a calorie restricting diet whilst on cycle.


Best MK-677 Supplements | 2023 Edition

With so many benefits of MK 677, you might be inclined to want to do further research on the product. For that endeavor we would highly suggest that you take a look at the Mk-677 offered by Chemyo.

Chemyo is one of the leading developers and retailers of research chemicals. Based in the States, Chemyo aims to provide a high-quality product at a cost-effective price, with no under dosing and no cutting of corners. All their products are third party tested to make sure the client will always be satisfied.

The MK 677 that Chemyo offers is dosed in a 50ml bottle, compared to other competitors which would be using a smaller container, meaning in the long run you could be spending less on shipping by using Chemyo. With great reviews on their website, the MK 677 is sure to deliver on the promise made by the manufacturer.

Here is where you can learn more:

Order MK-677 from the best USA vendor...

Benefits of MK-677 | Overall

Research chemicals have been tested by academics as well as independent researches with great success, and MK-677 seems to be leading the pack. With various benefits such as increased fat loss, improved sleep, and just a general increase in life quality, MK-677 could very well be a great addition to a supplement regime.

While safety is still advised, studies have found that conservative dosing over a conservative period of time has been nothing but beneficial to the test subjects. That being said, more research would always be welcomed.


  1. Ian M. Chapman, Ora H. Pescovitz, Gail Murphy, Theresa Treep, Kristine A. Cerchio, David Krupa, Barry Gertz, William J. Polvino, Emily H. Skiles, Suzan S. Pezzoli, Michael O. Thorner, Oral Administration of Growth Hormone (GH) Releasing Peptide-Mimetic MK-677 Stimulates the GH/Insulin-Like Growth Factor-I Axis in Selected GH-Deficient Adults, The Journal of Clinical Endocrinology & Metabolism, Volume 82, Issue 10, 1 October 1997, Pages 3455–3463,
  2. Nass R, Pezzoli SS, Oliveri MC, et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med. 2008;149(9):601-611. doi:10.7326/0003-4819-149-9-200811040-00003
  3. Ayuk J, Sheppard MC. Growth hormone and its disorders. Postgrad Med J. 2006;82(963):24-30. doi:10.1136/pgmj.2005.036087
  4. M. G. Murphy, L. M. Plunkett, B. J. Gertz, W. He, J. Wittreich, W. M. Polvino, D. R. Clemmons, MK-677, an Orally Active Growth Hormone Secretagogue, Reverses Diet-Induced Catabolism, The Journal of Clinical Endocrinology & Metabolism, Volume 83, Issue 2, 1 February 1998, Pages 320–325,
  6. Copinschi G, Leproult R, Van Onderbergen A, Caufriez A, Cole KY, Schilling LM, Mendel CM, De Lepeleire I, Bolognese JA, Van Cauter E. Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man. Neuroendocrinology. 1997 Oct;66(4):278-86. doi: 10.1159/000127249. PMID: 9349662.
  7. Copinschi G, Leproult R, Van Onderbergen A, Caufriez A, Cole KY, Schilling LM, Mendel CM, De Lepeleire I, Bolognese JA, Van Cauter E. Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man. Neuroendocrinology. 1997 Oct;66(4):278-86. doi: 10.1159/000127249. PMID: 9349662
  8. Rosenthal SM, Hulse JA, Kaplan SL, Grumbach MM. Exogenous growth hormone inhibits growth hormone-releasing factor-induced growth hormone secretion in normal men. J Clin Invest. 1986;77(1):176-180. doi:10.1172/JCI112273
  9. Kim SH, Park MJ. Effects of growth hormone on glucose metabolism and insulin resistance in human. Ann Pediatr Endocrinol Metab. 2017;22(3):145-152. doi:10.6065/apem.2017.22.3.145
  10. Hoffman DM, Crampton L, Sernia C, Nguyen TV, Ho KK. Short-term growth hormone (GH) treatment of GH-deficient adults increases body sodium and extracellular water, but not blood pressure. J Clin Endocrinol Metab. 1996 Mar;81(3):1123-8. doi: 10.1210/jcem.81.3.8772586. PMID: 8772586.
  11. Lampit M, Nave T, Hochberg Z. Water and sodium retention during short-term administration of growth hormone to short normal children. Horm Res. 1998;50(2):83-8. doi: 10.1159/000023239. PMID: 9701701.
  12. Pradhan G, Samson SL, Sun Y. Ghrelin: much more than a hunger hormone. Curr Opin Clin Nutr Metab Care. 2013;16(6):619-624. doi:10.1097/MCO.0b013e328365b9be
  13. Wilcox G. Insulin and insulin resistance. Clin Biochem Rev. 2005;26(2):19-39.
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