What is 5-Alpha-Hydroxy-Laxogenin?

Dr. Mike Jansen

Last Updated December 17, 2022

Dr. Mike Jansen

 December 17, 2022

Curious about 5-alpha-hydroxy-laxogenin?

Do you wonder if 5-alpha-hydroxy-laxogenin is the next big muscle-building supplement, or just another product that is all hype?

Then you’ve come to the right place. In this comprehensive guide, we detail everything you need to know about 5-alpha-hydroxy-laxogenin, including whether this product produces results in the real world.

We also answer your most important laxogenin questions, including:

  • Is laxogenin safe?
  • Who should take laxogenin?
  • How fast will I see results with this product?

…And so much more!

Our team has analyzed hundreds of verified customer reviews, as well as the latest scientific research to give you the facts around laxogenin, so you can make an informed decision.

Of course, at the end of the day you get to decide whether 5-alpha-hydroxy-laxogenin belongs in your supplement “stack.”

Now let’s get started!

Disclaimer: The contents of Testosterone.org are for informational and educational purposes. We do not provide legal advice. Likewise, we do not provide medical advice, diagnosis, or treatment. Please consult your physician prior to consuming any over-the-counter supplements, like a natural testosterone booster, and/or getting a prescription for a pharmaceutical medication. Your access to Testosterone.org is subject to our full disclaimer and terms of use.

What is 5a-Hydroxy-Laxogenin?

Laxogenin has a reputation as one of the most effective “legal steroid alternatives” on the market today.

But what is laxogenin, and why does it work so well for building muscle mass and strength?

Laxogenin belongs to a family of natural plant steroids called “brassinosteroids.” Laxogenin has been shown to dramatically increase protein synthesis in plants.

Many fitness experts believe that laxogenin should have a similar effect in humans, and there are plenty of research studies to support this claim.

Recent studies show that laxogenin and other brassinosteroids have the potential to boost protein synthesis levels in humans, increase AKT1 and cAMP levels, and even reduce free radical damage (1, 2, 3, 4, 5, 6, 7).

Unlike testosterone and other anabolic steroids, laxogenin does NOT impact your hormone levels. In fact, laxogenin does not bind to the androgen receptors in humans at all.

Instead, it is believed to directly increase protein synthesis levels inside your muscle cells.

This makes laxogenin completely different from traditional anabolic steroids, and a great choice for anyone who is trying to build muscle mass as a “natural” athlete.

Overall, the research on laxogenin is still in its early stages. We are still waiting for more long-term human studies to show just how effective laxogenin is. However, there is plenty of anecdotal evidence supporting laxogenin as a powerful “legal steroid alternative.”

Thousands of users all over the world are already using laxogenin, and with incredible results.


Laxogenin Benefits

You may be wondering about the potential benefits of laxogenin. After all, many first-time users are reporting incredible results with this “natural plant steroid.”

Based on our research, users report the following benefits while using laxogenin:

  • Rapid body composition changes
  • Faster overall strength gains
  • Improved recovery from intense workouts
  • Decreased stress levels
  • Improved quality of sleep

Let’s take a closer look at each of these benefits.

The primary reported benefit from taking laxogenin is rapid body composition changes. Many users report they look bigger AND leaner after using laxogenin for just 2-3 weeks!

This sounds too good to be true, but many other natural plant steroids have produced similar results in humans, so laxogenin may be the real deal. We think this might be related to laxogenin’s ability to increase protein synthesis levels, but it’s hard to say for sure.

Another reported benefit of laxogenin is faster overall strength gains.

Many users report their squat, bench press, deadlift, and other compound lifts increase significantly during their first laxogenin “cycle.”

Other reported benefits include improved recovery from intense workouts, decreased stress levels, and improved quality of sleep.

We recommend you carefully track your progress during your first laxogenin cycle. That way, you can determine for yourself whether this new supplement is giving you the results you want.

5-Alpha-Hydroxy-Laxogenin Side Effects

5-Alpha-Hydroxy-Laxogenin appears to be a very safe supplement.
Most users report no side effects while taking this product. However, some users experienced the following minor side effects:

  • Headaches
  • Nausea
  • Upset stomach
  • Heavy Urination

Let’s take a closer look at each of these side effects.

The most common side effects reported by users include headaches, nausea, and an upset stomach. This makes sense, as almost any supplement has the potential to induce these side effects.

Fortunately, these symptoms were relatively rare.

Only a small number of users reported these side effects, and the ones who did found relief by taking laxogenin with a whole food meal, or by reducing their dose.

Other possible side effects include heavy urination or kidney damage.

Our team was not able to find any users who experienced these more severe side effects. However, other Laxogenin resources list them as possible, so we included them here for the sake of completeness.

Of course, further research including human studies is required to identify all possible side effects associated with laxogenin.


Is Laxogenin Safe?

Laxogenin is quickly becoming one of the most popular new supplements in the fitness industry. But is it really safe? Based on our research, we believe the answer is a resounding “yes.”
Here are some of the reasons why laxogenin is probably safe for human consumption:

  • Natural plant steroid
  • Few user-reported side effects
  • Does not impact hormones
  • Does not require a PCT

Let’s take a closer look at each of these factors.

Laxogenin is a natural plant steroid. We know from research studies that other plant steroids like ecdysterone and turkesterone are perfectly safe. Therefore, it only makes sense that laxogenin would be as well.

In addition, laxogenin has very few reported side effects.

Thousands of individuals have completed their first laxogenin cycle, and almost no one experiences more than an upset stomach or a minor headache. And even those symptoms are relatively rare!

Finally, laxogenin does not impact your total testosterone levels or other hormones. Therefore, you don’t have to worry about any of the nasty side effects that anabolic steroids have.

Overall, we conclude that laxogenin is probably very safe for human consumption.

Of course, more research is required to confirm this statement.

Best 5a-Hydroxy-Laxogenin Supplement

Without further ado, here is the Testosterone.org list of the best laxogenin supplements available in 2023.

1. Huge Supplements Sapogenix

Our first choice for a high-quality laxogenin supplement has to be Huge Supplements Sapogenix.

Here at Testosterone.org, we are big fans of the Huge Supplements brand. They manufacture all of their products right here in the United States under tightly controlled facilities.

All of their products are tested by 3rd party facilities, so you know you are getting the highest quality product for your money.

Huge Supplements also has outstanding customer service, and some of the best shipping policies in the world. However, the thing that really separates Sapogenix from other laxogenin supplements is the product ingredients.

Sapogenix contains a potent blend of several different natural plant steroids, including 6-keto-disogenin, spirostanol sapogenins, furastanolic sapogenins, and many others.

Huge Supplements says these ingredients work synergistically to elevate protein synthesis levels, and based on user reviews, it looks like this is exactly what is happening.

Servings: 60

Amount per serving: 250 mg

Order Laxogenin from our top-rated USA vendor...

2. Huge Supplements Annihilate

Huge Supplements makes another great product called Annihilate.

This product contains 100 mg of pure laxogenin per capsule and nothing else. Huge Supplements Annihilate is a perfect choice for anyone who wants to get started with laxogenin, but isn’t ready to try a truly top-tier product like Sapogenix.

Servings: 60

Amount per serving: 100 mg

Order the best Laxogenin from Huge Supplements...

3. Redcon1 Halo

Redcon1 is one of the most trusted names in the fitness industry.

They are known for producing premium quality products from their United States based manufacturing facilities.

Inside each capsule f Redcon1 Halo is 100 mg of pure Chinese Smilax – the most potent form of laxogenin available anywhere in the world.

Servings: 60

Amount per serving: 100 mg

Click here if you want to learn more.

4. Hi-Tech Laxogenin 100

Hi-Tech Pharmaceuticals is another high-quality supplement brand. They produce a laxogenin product called Laxogenin 100 which is producing incredible results.

Servings: 60

Amount per serving: 100

Order the best Laxogenin from a USA vendor...

Laxogenin Dosage

By now you are probably wondering about the optimal laxogenin dosage.

In other words, how much laxogenin should you take to maximize your results, while minimizing any negative side effects?

Based on our research, the optimal laxogenin dosage is 100 – 200 mg per day for 6-12 weeks at a time. This dosage will maximize your size and strength gains and minimize any negative side effects.

Most users start out at a dose of 100 mg per day, and increase to 200 mg per day after realizing how effective laxogenin is. However, we recommend you take no more than 200 mg per day, as higher doses sometimes result in side effects like minor headaches or nausea.

Of course, further research is required to pinpoint the optimal laxogenin dose in humans.

Our recommendations are based on anecdotal evidence, such as product reviews from verified customers with no affiliation to any supplement company.

Most users choose to cycle laxogenin for 6-12 weeks at a time, and then take a short 1-2 month break from the product.

It’s not clear if this is necessary, as laxogenin does NOT impact your hormone levels. However, cycling laxogenin for 6-12 weeks at a time may be a smart decision, as there is no long-term research available on the product yet.


5-Alpha-Hydroxy-Laxogenin Cycle

5-alpha-hydroxy-laxogenin is a very powerful natural plant steroid.

5-alpha-hydroxy-laxogenin is so powerful, that many people believe you need to “cycle” this product to avoid serious side effects. But is that really true?

So far, we do not have any long-term studies on 5-alpha-hydroxy-laxogenin.

Because of this, it’s hard to say if it’s really necessary to cycle it. However, based on our research, we believe that cycling laxogenin is the way to go.

So what’s the best way to cycle laxogenin?

We recommend taking 100 – 200 mg of laxogenin per day for 6-12 weeks at a time.

After the first 6-12 weeks, you should take a 4-8 week break from laxogenin before starting your next cycle. This 1-2 month break is important for reducing the risk for any long-term side effects.

Most people start their cycle with 100 mg of laxogenin per day, and then quickly increase the dose to 200 mg per day after realizing how effective it is.

However, some users are getting great results at the initial 100 mg per day dose, so the choice is ultimately up to you.

5-Alpha-Hydroxy-Laxogenin | Overall

In conclusion…

5-alpha-hydroxy-laxogenin is one of the most powerful “legal steroid alternatives” in the world today.

This product has recently exploded in popularity, so there are few, if any, reliable research studies on it. However, the results from verified customers have been extremely impressive, which shows this product produce results in the real world.

More research is required to discover the optimal dosing protocol for this product.

However, based on anecdotal evidence and critical analysis, the optimal 5-alpha-hydroxy-laxgenin cycle is 100-200 mg per day for 6-12 weeks.

After that, a short break from the product is recommended to minimize the chance of experiencing side effects.

So what are you waiting for?

Pick up a bottle of 5-alpha-hydroxy-laxogenin today and take your fitness gains to the next level!


  1.  Bishop GJ, Koncz C. Brassinosteroids and plant steroid hormone signaling. Plant Cell. 2002;14 Suppl(Suppl):S97-S110. doi:10.1105/tpc.001461
  2. Wang Q, Xu J, Liu X, Gong W, Zhang C. Synthesis of brassinosteroids analogues from laxogenin and their plant growth promotion. Nat Prod Res. 2015;29(2):149-57. doi: 10.1080/14786419.2014.968151. Epub 2014 Oct 14. PMID: 25311045.
  3. Hajduch E, Alessi DR, Hemmings BA, Hundal HS. Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells. Diabetes. 1998 Jul;47(7):1006-13. doi: 10.2337/diabetes.47.7.1006. PMID: 9648821.
  4. Rommel C, Bodine SC, Clarke BA, Rossman R, Nunez L, Stitt TN, Yancopoulos GD, Glass DJ. Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways. Nat Cell Biol. 2001 Nov;3(11):1009-13. doi: 10.1038/ncb1101-1009. PMID: 11715022.
  5. Additionally, natural laxogenin derivatives block the enzyme that breaks down cAMP (phosphodiesterase). This increases cAMP levels, enhancing fat breakdown and activating the fight-or-flight (sympathetic) response (16)
  6. Zhang YW, Morita I, Zhang L, Shao G, Yao XS, Murota S. Screening of anti-hypoxia/reoxygenation agents by an in vitro method. Part 2: Inhibition of tyrosine kinase activation prevented hypoxia/reoxygenation-induced injury in endothelial gap junctional intercellular communication. Planta Med. 2000 Mar;66(2):119-23. doi: 10.1055/s-2000-11126. PMID: 10763583.
  7. Zhang YW, Morita I, Shao G, Yao XS, Murota S. Screening of anti-hypoxia/reoxygenation agents by an in vitro model. Part 1: Natural inhibitors for protein tyrosine kinase activated by hypoxia/reoxygenation in cultured human umbilical vein endothelial cells. Planta Med. 2000 Mar;66(2):114-8. doi: 10.1055/s-2000-11128. PMID: 10763582.
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